Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain
Thioredoxin, encoded by Txn1, acts as a critical antioxidant in the defense against oxidative stress by regulating the dithiol/disulfide balance of interacting proteins.The role of thioredoxin in the central nervous system (CNS) is largely unknown.A phenotype-driven study of N-ethyl-N-nitrosourea-mutated rats with wild-running seizures revealed the