THIOREDOXIN DEFICIENCY INCREASES OXIDATIVE STRESS AND CAUSES BILATERAL SYMMETRICAL DEGENERATION IN RAT MIDBRAIN

Thioredoxin deficiency increases oxidative stress and causes bilateral symmetrical degeneration in rat midbrain

Thioredoxin, encoded by Txn1, acts as a critical antioxidant in the defense against oxidative stress by regulating the dithiol/disulfide balance of interacting proteins.The role of thioredoxin in the central nervous system (CNS) is largely unknown.A phenotype-driven study of N-ethyl-N-nitrosourea-mutated rats with wild-running seizures revealed the

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